My sister always complains that she is having a headache that is on one side of her head. She closes the curtain of Windows and door and makes her room dark because she can't tolerate light. Pain doesn't go away unless she takes some painkillers. She is suffering from Migraine headaches. Migraine is the 3rd most prevalent and 6th most disabling disease in the world. Migraine is a primary headache disorder characterized by recurrent headaches that are moderate to severe. Most often, the headaches affect one half of the head, are pulsating in nature, and last from two to 72 hours. It usually comes on gradually and is aggravated by physical activity. The cause of Migraine is unknown. However, it is believed to be an environmental and genetic factor. Women are three times more likely to have migraines. Headaches tend to affect boys more than girls during childhood, but by the time of puberty and beyond, more girls are affected. An aura is a prior stage of migraine which may occur up to one-third of people. It is a short period of visual disturbance which signals that the headache will soon occur. The associated symptoms of Migraine may include nausea, vomiting, and sensitivity to light, sound, or smell. People who have migraines with aura are more likely to have strokes caused by either a blood clot in the heart (cardio-embolic stroke) or a clot within the brain’s blood vessels (thrombotic stroke), compared to those that don’t have migraines with aura, according to research presented at the American Stroke Association’s International Stroke Conference 2016. Preventive treatments of migraines include medications, nutritional supplements, and lifestyle alterations. The recommended initial treatment for those with mild to moderate symptoms is simple analgesics such as non-steroidal anti-inflammatory drugs (NSAIDs) or the combination of paracetamol, aspirin, and caffeine. However, consultation with the doctor for proper diagnosis and treatment is necessary.